Sleep disturbances such as insomnia, restless sleep, REM sleep behaviour disorder, and excessive daytime sleepiness have been observed in patients before a formal diagnosis of conditions like MS [6]
These studies have observed reductions in cigarette consumption ranging from 20 to 42% (Dalack and Meador-Woodruff, 1999

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Insufficient Data Transparency and Scientific Oversight: Although TPD II capped nicotine at 20 mg/mL, it lacks dynamic assessment mechanisms for emissions, toxicology, and long-term health impacts